Desmosome mutations impact the tumor microenvironment to promote melanoma proliferation

Desmosomes are transmembrane protein complexes that contribute to cell-cell adhesion in epithelia and other tissues. Here, we report the discovery of frequent genetic alterations in the desmosome in human cancers, with the strongest signal seen in cutaneous melanoma where desmosomes are mutated in o...

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Detalles Bibliográficos
Autores principales: Baron, Maayan, Tagore, Mohita, Wall, Patrick, Zheng, Fan, Barkley, Dalia, Yanai, Itai, Yang, Jing, Kiuru, Maija, White, Richard M., Ideker, Trey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541613/
https://www.ncbi.nlm.nih.gov/pubmed/37786690
http://dx.doi.org/10.1101/2023.09.19.558457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541613/
https://www.ncbi.nlm.nih.gov/pubmed/37786690
http://dx.doi.org/10.1101/2023.09.19.558457

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