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Unraveling the Structure of Meclizine Dihydrochloride with MicroED

Meclizine (Antivert, Bonine) is a first-generation H1 antihistamine used in the treatment of motion sickness and vertigo. Despite its wide medical use for over 70 years, its crystal structure and the details of protein-drug interactions remained unknown. In this study, we used microcrystal electron...

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Detalles Bibliográficos
Autores principales: Lin, Jieye, Unge, Johan, Gonen, Tamir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541648/
https://www.ncbi.nlm.nih.gov/pubmed/37786674
http://dx.doi.org/10.1101/2023.09.05.556418