Cystine/glutamate antiporter System x(c)(-) deficiency impairs insulin secretion in mice

AIMS/HYPOTHESIS: Glutamate-induced cytotoxicity (excitotoxicity) has been detected in pancreatic beta cells. The cystine/glutamate antiporter System x(c)(-) exports glutamate to the extracellular space and is therefore implicated as driving excitotoxicity. As of yet, it has not been investigated whe...

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Detalles Bibliográficos
Autores principales: de Baat, Axel, Meier, Daniel T., Rachid, Leila, Fontana, Adriano, Böni-Schnetzler, Marianne, Donath, Marc Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541846/
https://www.ncbi.nlm.nih.gov/pubmed/37650924
http://dx.doi.org/10.1007/s00125-023-05993-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541846/
https://www.ncbi.nlm.nih.gov/pubmed/37650924
http://dx.doi.org/10.1007/s00125-023-05993-6

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