Cell cycle progression mechanisms: slower cyclin-D/CDK4 activation and faster cyclin-E/CDK2

Dysregulation of cyclin-dependent kinases (CDKs) impacts cell proliferation, driving cancer. Here, we ask why the cyclin-D/CDK4 complex governs cell cycle progression through the longer G1 phase, whereas cyclin-E/CDK2 regulates the short G1/S phase transition. We consider the experimentally establis...

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Detalles Bibliográficos
Autores principales: Zhang, Wengang, Liu, Yonglan, Jang, Hyunbum, Nussinov, Ruth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542123/
https://www.ncbi.nlm.nih.gov/pubmed/37790340
http://dx.doi.org/10.1101/2023.08.16.553605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542123/
https://www.ncbi.nlm.nih.gov/pubmed/37790340
http://dx.doi.org/10.1101/2023.08.16.553605

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