Cargando…

Cell cycle progression mechanisms: slower cyclin-D/CDK4 activation and faster cyclin-E/CDK2

Dysregulation of cyclin-dependent kinases (CDKs) impacts cell proliferation, driving cancer. Here, we ask why the cyclin-D/CDK4 complex governs cell cycle progression through the longer G1 phase, whereas cyclin-E/CDK2 regulates the short G1/S phase transition. We consider the experimentally establis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Wengang, Liu, Yonglan, Jang, Hyunbum, Nussinov, Ruth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542123/ https://www.ncbi.nlm.nih.gov/pubmed/37790340 http://dx.doi.org/10.1101/2023.08.16.553605

Ejemplares similares

Molecular docking analysis of piperine with CDK2,CDK4,Cyclin D and Cyclin T proteins
por: Rekha, Umapathy Vidhya, et al.
Publicado: (2020)

Nuclear Import of Cdk/Cyclin Complexes: Identification of Distinct Mechanisms for Import of Cdk2/Cyclin E and Cdc2/Cyclin B1
por: Moore, Jonathan D., et al.
Publicado: (1999)

Caenorhabditis elegans Cyclin D/CDK4 and Cyclin E/CDK2 Induce Distinct Cell Cycle Re-Entry Programs in Differentiated Muscle Cells
por: Korzelius, Jerome, et al.
Publicado: (2011)

Comparison of deregulated expression of cyclin D1 and cyclin E with that of cyclin-dependent kinase 4 (CDK4) and CDK2 in human oesophageal squamous cell carcinoma
por: Matsumoto, M, et al.
Publicado: (1999)

Cyclin K goes with Cdk12 and Cdk13
por: Kohoutek, Jiri, et al.
Publicado: (2012)

Temporal changes in cyclinD-CDK4/CDK6 and cyclinE-CDK2 pathways: implications for the mechanism of deficient decidualization in an immune-based mouse model of unexplained recurrent spontaneous abortion
por: Chang, Zhuo, et al.
Publicado: (2022)

Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein
Publicado: (1996)

Cyclin D1-CDK4 Controls Glucose Metabolism Independently of Cell Cycle Progression
por: Lee, Yoonjin, et al.
Publicado: (2014)

Lineage specific composition of cyclin D–CDK4/CDK6–p27 complexes reveals distinct functions of CDK4, CDK6 and individual D‐type cyclins in differentiating cells of embryonic origin
por: Bryja, V., et al.
Publicado: (2008)

Rising Cyclin-CDK Levels Order Cell Cycle Events
por: Oikonomou, Catherine, et al.
Publicado: (2011)

Cytoplasmic division cycles without the nucleus and mitotic CDK/cyclin complexes
por: Bakshi, Anand, et al.
Publicado: (2023)

Cyclin-Specific Docking Mechanisms Reveal the Complexity of M-CDK Function in the Cell Cycle
por: Örd, Mihkel, et al.
Publicado: (2019)

Protein conformational ensembles in function: roles and mechanisms
por: Nussinov, Ruth, et al.
Publicado: (2023)

Cyclin B/CDK1 and Cyclin A/CDK2 phosphorylate DENR to promote mitotic protein translation and faithful cell division
por: Clemm von Hohenberg, Katharina, et al.
Publicado: (2022)

Cyclin E1-CDK 2, a potential anticancer target
por: Fang, Dongdong, et al.
Publicado: (2016)

Cell cycle transcriptomics of Capsaspora provides insights into the evolution of cyclin-CDK machinery
por: Pérez-Posada, Alberto, et al.
Publicado: (2020)

A novel role for the cell cycle regulatory complex cyclin D1–CDK4 in gluconeogenesis
por: Hosooka, Tetsuya, et al.
Publicado: (2015)

Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2
por: Pack, Lindsey R., et al.
Publicado: (2021)

Phylogenetic analysis of CDK and cyclin proteins in premetazoan lineages
por: Cao, Lihuan, et al.
Publicado: (2014)

Structural insights into the functional diversity of the CDK–cyclin family
por: Wood, Daniel J., et al.
Publicado: (2018)

The awakening of the CDK10/Cyclin M protein kinase
por: Guen, Vincent J., et al.
Publicado: (2017)

CDK4, CDK6/cyclin-D1 Complex Inhibition and Radiotherapy for Cancer Control: A Role for Autophagy
por: Nardone, Valerio, et al.
Publicado: (2021)

CDK-Dependent Hsp70 Phosphorylation Controls G1 Cyclin Abundance and Cell-Cycle Progression
por: Truman, Andrew W., et al.
Publicado: (2012)

PKM2 Interacts With the Cdk1-CyclinB Complex to Facilitate Cell Cycle Progression in Gliomas
por: Ohba, Shigeo, et al.
Publicado: (2022)

Cyclin D-CDK4 relieves cooperative repression of proliferation and cell cycle gene expression by DREAM and RB.
por: Schade, Amy E., et al.
Publicado: (2019)

CDK/cyclin dependencies define extreme cancer cell-cycle heterogeneity and collateral vulnerabilities
por: Knudsen, Erik S., et al.
Publicado: (2022)

Break CDK2/Cyclin E1 Interface Allosterically with Small Peptides
por: Chen, Hao, et al.
Publicado: (2014)

Cyclin E/CDK2: DNA Replication, Replication Stress and Genomic Instability
por: Fagundes, Rafaela, et al.
Publicado: (2021)

Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacy
por: Gharbi, Severine Isabelle, et al.
Publicado: (2022)

Cyclin I-like (CCNI2) is a cyclin-dependent kinase 5 (CDK5) activator and is involved in cell cycle regulation
por: Liu, Chengcheng, et al.
Publicado: (2017)

The Cyclin-dependent Kinase Cdk2 Regulates Thymocyte Apoptosis
por: Hakem, Anne, et al.
Publicado: (1999)

The structure and substrate specificity of human Cdk12/Cyclin K
por: Bösken, Christian A., et al.
Publicado: (2014)

Cyclin-dependent kinases and CDK inhibitors in virus-associated cancers
por: Tavakolian, Shaian, et al.
Publicado: (2020)

Cyclin-Dependent Kinases (CDK) and Their Role in Diseases Development–Review
por: Łukasik, Paweł, et al.
Publicado: (2021)

Functional characterization of the human Cdk10/Cyclin Q complex
por: Düster, Robert, et al.
Publicado: (2022)

Extra-cell cycle regulatory functions of cyclin-dependent kinases (CDK) and CDK inhibitor proteins contribute to brain development and neurological disorders
por: Kawauchi, Takeshi, et al.
Publicado: (2013)

Osthole Alleviates Neointimal Hyperplasia in Balloon-Induced Arterial Wall Injury by Suppressing Vascular Smooth Muscle Cell Proliferation and Downregulating Cyclin D1/CDK4 and Cyclin E1/CDK2 Expression
por: Li, Yi-Qi, et al.
Publicado: (2021)

Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells
por: Zhang, Jiawei, et al.
Publicado: (2022)

A Requirement for Cyclin D3–Cyclin-dependent Kinase (cdk)-4 Assembly in the Cyclic Adenosine Monophosphate–dependent Proliferation of Thyrocytes
por: Depoortere, Fabienne, et al.
Publicado: (1998)

Cul4B promotes the progression of ovarian cancer by upregulating the expression of CDK2 and CyclinD1
por: Duan, Peng-jing, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_0qi2qr39pa695it4ivnjudcsic