Homologous Recombination Abnormalities Associated With BRCA1/2 Mutations as Predicted by Machine Learning of Targeted Next-Generation Sequencing Data

BACKGROUND: Homologous recombination deficiency (HRD) is the hallmark of breast cancer gene 1/2 (BRCA1/2)-mutated tumors and the unique biomarker for predicting response to double-strand break (DSB)–inducing drugs. The demonstration of HRD in tumors with mutations in genes other than BRCA1/2 is cons...

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Detalles Bibliográficos
Autores principales: Albitar, Maher, Zhang, Hong, Pecora, Andrew, Waintraub, Stanley, Graham, Deena, Hellmann, Mira, McNamara, Donna, Charifa, Ahmad, De Dios, Ivan, Ma, Wanlong, Goy, Andre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542224/
https://www.ncbi.nlm.nih.gov/pubmed/37789896
http://dx.doi.org/10.1177/11782234231198979

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542224/
https://www.ncbi.nlm.nih.gov/pubmed/37789896
http://dx.doi.org/10.1177/11782234231198979

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