The RNA m5C modification in R-loops as an off switch of Alt-NHEJ

The roles of R-loops and RNA modifications in homologous recombination (HR) and other DNA double-stranded break (DSB) repair pathways remain poorly understood. Here, we find that DNA damage-induced RNA methyl-5-cytosine (m5C) modification in R-loops plays a crucial role to regulate PARP1-mediated po...

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Detalles Bibliográficos
Autores principales: Yang, Haibo, Lachtara, Emily M., Ran, Xiaojuan, Hopkins, Jessica, Patel, Parasvi S., Zhu, Xueping, Xiao, Yao, Phoon, Laiyee, Gao, Boya, Zou, Lee, Lawrence, Michael S., Lan, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542358/
https://www.ncbi.nlm.nih.gov/pubmed/37777505
http://dx.doi.org/10.1038/s41467-023-41790-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542358/
https://www.ncbi.nlm.nih.gov/pubmed/37777505
http://dx.doi.org/10.1038/s41467-023-41790-w

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