Cargando…

The RNA m5C modification in R-loops as an off switch of Alt-NHEJ

The roles of R-loops and RNA modifications in homologous recombination (HR) and other DNA double-stranded break (DSB) repair pathways remain poorly understood. Here, we find that DNA damage-induced RNA methyl-5-cytosine (m5C) modification in R-loops plays a crucial role to regulate PARP1-mediated po...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Haibo, Lachtara, Emily M., Ran, Xiaojuan, Hopkins, Jessica, Patel, Parasvi S., Zhu, Xueping, Xiao, Yao, Phoon, Laiyee, Gao, Boya, Zou, Lee, Lawrence, Michael S., Lan, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542358/ https://www.ncbi.nlm.nih.gov/pubmed/37777505 http://dx.doi.org/10.1038/s41467-023-41790-w

Ejemplares similares

FMRP promotes transcription-coupled homologous recombination via facilitating TET1-mediated m5C RNA modification demethylation
por: Yang, Haibo, et al.
Publicado: (2022)

An R-loop-initiated CSB–RAD52–POLD3 pathway suppresses ROS-induced telomeric DNA breaks
por: Tan, Jun, et al.
Publicado: (2020)

Recommendations on diagnosis and treatment in hepatobiliary surgery under 2019-nCoV epidemic
por: Phoon, Laiyee, et al.
Publicado: (2020)

Inactivation of Pol θ and C-NHEJ eliminates off-target integration of exogenous DNA
por: Zelensky, Alex N., et al.
Publicado: (2017)

Repair of chromosomal breaks by NHEJ
por: Reid, Dylan A., et al.
Publicado: (2015)

The high toxicity of DSB-clusters modelling high-LET-DNA damage derives from inhibition of c-NHEJ and promotion of alt-EJ and SSA despite increases in HR
por: Mladenova, Veronika, et al.
Publicado: (2022)

How do telomeres and NHEJ coexist?
por: Marcand, Stéphane
Publicado: (2014)

YALIcloneNHEJ: An Efficient Modular Cloning Toolkit for NHEJ Integration of Multigene Pathway and Terpenoid Production in Yarrowia lipolytica
por: Li, Ya-Wen, et al.
Publicado: (2022)

DNA-PK(cs)-dependent phosphorylation of RECQL4 promotes NHEJ by stabilizing the NHEJ machinery at DNA double-strand breaks
por: Lu, Huiming, et al.
Publicado: (2022)

Papillon Flap—Design Modification of ALT Flap for Circumferential Laryngopharyngeal Defect
por: Singh, Sukhdeep, et al.
Publicado: (2023)

Tocilizumab: Elevated AST and ALT following off label therapy: 11 case reports
Publicado: (2021)

FANCM suppresses DNA replication stress at ALT telomeres by disrupting TERRA R-loops
por: Pan, Xiaolei, et al.
Publicado: (2019)

DNA-binding determinants promoting NHEJ by human Polµ
por: Martin, Maria Jose, et al.
Publicado: (2012)

PAXX, Not NHEJ1 Is an Independent Prognosticator in Colon Cancer
por: Arora, Mohit, et al.
Publicado: (2020)

Biochemical evidence for Ku-independent backup pathways of NHEJ
por: Wang, Huichen, et al.
Publicado: (2020)

Switch telomerase to ALT mechanism by inducing telomeric DNA damages and dysfunction of ATRX and DAXX
por: Hu, Yang, et al.
Publicado: (2016)

Remdesivir: Elevated AST and ALT levels following off-label therapy: 4 case reports
Publicado: (2020)

HTLV-I Tax Increases Genetic Instability by Inducing DNA Double Strand Breaks during DNA Replication and Switching Repair to NHEJ
por: Baydoun, Hicham H., et al.
Publicado: (2012)

Sister telomeres rendered dysfunctional by persistent cohesion are fused by NHEJ
por: Hsiao, Susan J., et al.
Publicado: (2009)

A Sir2-Like Protein Participates in Mycobacterial NHEJ
por: Li, Zhongdao, et al.
Publicado: (2011)

Molecular basis for DNA strand displacement by NHEJ repair polymerases
por: Bartlett, Edward J., et al.
Publicado: (2016)

Polμ tumor variants decrease the efficiency and accuracy of NHEJ
por: Sastre-Moreno, Guillermo, et al.
Publicado: (2017)

An immunocompetent patient with a nonsense mutation in NHEJ1 gene
por: Esmaeilzadeh, Hossein, et al.
Publicado: (2019)

XLF-mediated NHEJ activity in hepatocellular carcinoma therapy resistance
por: Yang, Sitian, et al.
Publicado: (2017)

Molecular basis for assembly of the shieldin complex and its implications for NHEJ
por: Liang, Ling, et al.
Publicado: (2020)

Predictable NHEJ Insertion and Assessment of HDR Editing Strategies in Plants
por: Molla, Kutubuddin A., et al.
Publicado: (2022)

Cryo-EM of NHEJ supercomplexes provides insights into DNA repair
por: Chaplin, Amanda K., et al.
Publicado: (2021)

PAXX binding to the NHEJ machinery explains functional redundancy with XLF
por: Seif-El-Dahan, Murielle, et al.
Publicado: (2023)

Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ
por: Chen, Siyu, et al.
Publicado: (2023)

Metastasis Suppressor NME1 Modulates Choice of Double-Strand Break Repair Pathways in Melanoma Cells by Enhancing Alternative NHEJ while Inhibiting NHEJ and HR
por: Puts, Gemma, et al.
Publicado: (2020)

A new assay capturing chromosome fusions shows a protection trade-off at telomeres and NHEJ vulnerability to low-density ionizing radiation
por: Pobiega, Sabrina, et al.
Publicado: (2021)

Galerie Alte Meister /
Publicado: (1979)

Alte nationalgalerie Berlin

Ctrl alt share
Publicado: (2015)

The Alt-Scherbitz Asylum
Publicado: (1898)

Alt HealthWatch
por: Christianson, Merete
Publicado: (2017)

Effects of BRCA2 deficiency on telomere recombination in non-ALT and ALT cells
por: Sapir, Ester, et al.
Publicado: (2011)

G-quadruplex Stabilization Fuels the ALT Pathway in ALT-positive Osteosarcoma Cells
por: Amato, Roberta, et al.
Publicado: (2020)

Remdesivir: Elevated ALT level and lack of efficacy following off-label use: 13 case reports
Publicado: (2021)

FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops
por: Silva, Bruno, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_lerpu1ob8k5rlo255nn2qeenho