PAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development

The coding variant (p.Arg192His) in the transcription factor PAX4 is associated with an altered risk for type 2 diabetes (T2D) in East Asian populations. In mice, Pax4 is essential for beta cell formation but its role on human beta cell development and/or function is unknown. Participants carrying t...

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Detalles Bibliográficos
Autores principales: Lau, Hwee Hui, Krentz, Nicole A. J., Abaitua, Fernando, Perez-Alcantara, Marta, Chan, Jun-Wei, Ajeian, Jila, Ghosh, Soumita, Lee, Yunkyeong, Yang, Jing, Thaman, Swaraj, Champon, Benoite, Sun, Han, Jha, Alokkumar, Hoon, Shawn, Tan, Nguan Soon, Gardner, Daphne Su-Lyn, Kao, Shih Ling, Tai, E. Shyong, Gloyn, Anna L., Teo, Adrian Kee Keong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542369/
https://www.ncbi.nlm.nih.gov/pubmed/37777536
http://dx.doi.org/10.1038/s41467-023-41860-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542369/
https://www.ncbi.nlm.nih.gov/pubmed/37777536
http://dx.doi.org/10.1038/s41467-023-41860-z

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