SIRT2 alleviated renal fibrosis by deacetylating SMAD2 and SMAD3 in renal tubular epithelial cells

Transforming growth factor-β (TGF-β) is the primary factor that drives fibrosis in most, if not all, forms of chronic kidney disease. In kidneys that are obstructed, specific deletion of Sirt2 in renal tubule epithelial cells (TEC) has been shown to aggravate renal fibrosis, while renal tubule speci...

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Detalles Bibliográficos
Autores principales: Yang, Shu, Yang, Guangyan, Wang, Xinyu, Xiang, Jiaqing, Kang, Lin, Liang, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542381/
https://www.ncbi.nlm.nih.gov/pubmed/37777567
http://dx.doi.org/10.1038/s41419-023-06169-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542381/
https://www.ncbi.nlm.nih.gov/pubmed/37777567
http://dx.doi.org/10.1038/s41419-023-06169-1

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