IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxia

The proline synthesis is importantly involved in tumor growth under hypoxia, while the underlying mechanism remains to be further investigated. Here we show that pyrroline-5-carpoxylate reductase-1 (PYCR1), displaying a constant nuclear localization, is phosphorylated by nuclear IGF1R at Tyrosine 13...

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Detalles Bibliográficos
Autores principales: Zheng, Ke, Sha, Nannan, Hou, Guofang, Leng, Zhuyun, Zhao, Qin, Zhang, Li, He, Lingnan, Xu, Meidong, Jiang, Yuhui, Chen, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542766/
https://www.ncbi.nlm.nih.gov/pubmed/37777542
http://dx.doi.org/10.1038/s41467-023-41658-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542766/
https://www.ncbi.nlm.nih.gov/pubmed/37777542
http://dx.doi.org/10.1038/s41467-023-41658-z

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