Fast, multiplexable and efficient somatic gene deletions in adult mouse skeletal muscle fibers using AAV-CRISPR/Cas9

Molecular screens comparing different disease states to identify candidate genes rely on the availability of fast, reliable and multiplexable systems to interrogate genes of interest. CRISPR/Cas9-based reverse genetics is a promising method to eventually achieve this. However, such methods are sorel...

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Detalles Bibliográficos
Autores principales: Thürkauf, Marco, Lin, Shuo, Oliveri, Filippo, Grimm, Dirk, Platt, Randall J., Rüegg, Markus A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542775/
https://www.ncbi.nlm.nih.gov/pubmed/37777530
http://dx.doi.org/10.1038/s41467-023-41769-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542775/
https://www.ncbi.nlm.nih.gov/pubmed/37777530
http://dx.doi.org/10.1038/s41467-023-41769-7

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