Discovery of a cystathionine γ-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5′-phosphate (PLP) via Schiff base formation

D,L-Propargylglycine (PAG) has been widely used as a selective inhibitor to investigate the biological functions of cystathionine γ-lyase (CSE), which catalyzes the formation of reactive sulfur species (RSS). However, PAG also inhibits other PLP (pyridoxal-5′-phosphate)-dependent enzymes such as met...

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Detalles Bibliográficos
Autores principales: Echizen, Honami, Hanaoka, Kenjiro, Shimamoto, Kazuhito, Hibi, Ryota, Toma-Fukai, Sachiko, Ohno, Hisashi, Sasaki, Eita, Komatsu, Toru, Ueno, Tasuku, Tsuchiya, Yukihiro, Watanabe, Yasuo, Otsuka, Takao, Saito, Hiroaki, Nagatoishi, Satoru, Tsumoto, Kouhei, Kojima, Hirotatsu, Okabe, Takayoshi, Shimizu, Toshiyuki, Urano, Yasuteru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542788/
https://www.ncbi.nlm.nih.gov/pubmed/37777556
http://dx.doi.org/10.1038/s41598-023-43536-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542788/
https://www.ncbi.nlm.nih.gov/pubmed/37777556
http://dx.doi.org/10.1038/s41598-023-43536-6

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