A possible role for proinflammatory activation via cGAS-STING pathway in atherosclerosis induced by accumulation of DNA double-strand breaks

DNA damage contributes to atherosclerosis. However, causative links between DNA double-strand breaks (DSBs) and atherosclerosis have yet to be established. Here, we investigated the role of DSBs in atherosclerosis using mice and vascular cells deficient in Ku80, a DSB repair protein. After 4 weeks o...

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Detalles Bibliográficos
Autores principales: Sakai, Chiemi, Ueda, Keitaro, Goda, Kohei, Fujita, Rikuto, Maeda, Junji, Nakayama, Shinya, Sotomaru, Yusuke, Tashiro, Satoshi, Yoshizumi, Masao, Ishida, Takafumi, Ishida, Mari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542807/
https://www.ncbi.nlm.nih.gov/pubmed/37777633
http://dx.doi.org/10.1038/s41598-023-43848-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542807/
https://www.ncbi.nlm.nih.gov/pubmed/37777633
http://dx.doi.org/10.1038/s41598-023-43848-7

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