Fuzzy interactions between the auto-phosphorylated C-terminus and the kinase domain of CK1δ inhibits activation of TAp63α

The p53 family member TAp63α plays an important role in maintaining the genetic integrity in oocytes. DNA damage, in particular DNA double strand breaks, lead to the transformation of the inhibited, only dimeric conformation into the active tetrameric one that results in the initiation of an apoptot...

Descripción completa

Detalles Bibliográficos
Autores principales: Lambert, Mahil, Gebel, Jakob, Trejtnar, Charlotte, Wesch, Nicole, Bozkurt, Süleyman, Adrian-Allgood, Martin, Löhr, Frank, Münch, Christian, Dötsch, Volker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542812/
https://www.ncbi.nlm.nih.gov/pubmed/37777570
http://dx.doi.org/10.1038/s41598-023-43515-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542812/
https://www.ncbi.nlm.nih.gov/pubmed/37777570
http://dx.doi.org/10.1038/s41598-023-43515-x

Ejemplares similares