Co-targeting BCL-XL and BCL-2 by PROTAC 753B eliminates leukemia cells and enhances efficacy of chemotherapy by targeting senescent cells

BCL-X(L) and BCL-2 are key anti-apoptotic proteins and validated cancer targets. 753B is a novel BCL-X(L)/BCL-2 proteolysis targeting chimera (PROTAC) that targets both BCL-X(L) and BCL-2 to the von Hippel-Lindau (VHL) E3 ligase, leading to BCL-X(L)/BCL-2 ubiquitination and degradation selectively i...

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Detalles Bibliográficos
Autores principales: Jia, Yannan, Han, Lina, Ramage, Cassandra L., Wang, Zhe, Weng, Connie C., Yang, Lei, Colla, Simona, Ma, Helen, Zhang, Weiguo, Andreeff, Michael, Daver, Naval, Jain, Nitin, Pemmaraju, Naveen, Bhalla, Kapil, Mustjoki, Satu, Zhang, Peiyi, Zheng, Guangrong, Zhou, Daohong, Zhang, Qi, Konopleva, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2023
Materias:
Article - Acute Myeloid Leukemia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542840/
https://www.ncbi.nlm.nih.gov/pubmed/37078252
http://dx.doi.org/10.3324/haematol.2022.281915

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542840/
https://www.ncbi.nlm.nih.gov/pubmed/37078252
http://dx.doi.org/10.3324/haematol.2022.281915

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