Pooled endogenous protein tagging and recruitment for scalable discovery of effectors for induced proximity therapeutics

The field of induced proximity therapeutics is in its ascendancy but is limited by a lack of scalable tools to systematically explore effector-target protein pairs in an unbiased manner. Here, we combined Scalable POoled Targeting with a LIgandable Tag at Endogenous Sites (SPOTLITES) for the high-th...

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Detalles Bibliográficos
Autores principales: Serebrenik, Yevgeniy V., Mani, Deepak, Maujean, Timothé, Burslem, George M., Shalem, Ophir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543026/
https://www.ncbi.nlm.nih.gov/pubmed/37790450
http://dx.doi.org/10.21203/rs.3.rs-3161717/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543026/
https://www.ncbi.nlm.nih.gov/pubmed/37790450
http://dx.doi.org/10.21203/rs.3.rs-3161717/v1

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