Pathway-Specific Polygenic Scores Improve Cross-Ancestry Prediction of Psychosis and Clinical Outcomes

Psychotic disorders are debilitating conditions with disproportionately high public health burden. Genetic studies indicate high heritability, but current polygenic scores (PGS) account for only a fraction of variance in psychosis risk. PGS often show poor portability across ancestries, performing s...

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Detalles Bibliográficos
Autores principales: Tubbs, Justin D., Leung, Perry B.M., Zhong, Yuanxin, Zhan, Na, Hui, Tomy C.K., Ho, Karen K.Y., Hung, Karen S.Y., Cheung, Eric F.C., So, Hon-Cheong, Lui, Simon S.Y., Sham, Pak C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543247/
https://www.ncbi.nlm.nih.gov/pubmed/37790317
http://dx.doi.org/10.1101/2023.09.01.23294957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543247/
https://www.ncbi.nlm.nih.gov/pubmed/37790317
http://dx.doi.org/10.1101/2023.09.01.23294957

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