Cargando…
Pathway-Specific Polygenic Scores Improve Cross-Ancestry Prediction of Psychosis and Clinical Outcomes
Psychotic disorders are debilitating conditions with disproportionately high public health burden. Genetic studies indicate high heritability, but current polygenic scores (PGS) account for only a fraction of variance in psychosis risk. PGS often show poor portability across ancestries, performing s...
Autores principales: | Tubbs, Justin D., Leung, Perry B.M., Zhong, Yuanxin, Zhan, Na, Hui, Tomy C.K., Ho, Karen K.Y., Hung, Karen S.Y., Cheung, Eric F.C., So, Hon-Cheong, Lui, Simon S.Y., Sham, Pak C. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543247/ https://www.ncbi.nlm.nih.gov/pubmed/37790317 http://dx.doi.org/10.1101/2023.09.01.23294957 |
Ejemplares similares
-
Improving polygenic risk prediction from summary statistics by an empirical Bayes approach
por: So, Hon-Cheong, et al.
Publicado: (2017) -
Association of neurotransmitter pathway polygenic risk with specific symptom profiles in psychosis
por: Warren, Tracy L., et al.
Publicado: (2023) -
The genetic basis of onset age in schizophrenia: evidence and models
por: Zhan, Na, et al.
Publicado: (2023) -
Performance of African-ancestry-specific polygenic hazard score varies according to local ancestry in 8q24
por: Karunamuni, Roshan A., et al.
Publicado: (2022) -
On cross-ancestry cancer polygenic risk scores
por: Fritsche, Lars G., et al.
Publicado: (2021)