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CNS Repopulation by Hematopoietic-Derived Microglia-Like Cells Corrects Progranulin deficiency

Hematopoietic stem cell transplantation can deliver therapeutic proteins to the CNS through donor-derived hematopoietic cells that become microglia-like cells. However, using standard conditioning approaches, hematopoietic stem cell transplantation is currently limited by low and slow engraftment of...

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Detalles Bibliográficos
Autores principales: Colella, Pasqualina, Sayana, Ruhi, Suarez-Nieto, Maria Valentina, Sarno, Jolanda, Nyame, Kwamina, Xiong, Jian, Vera, Luisa Natalia Pimentel, Basurto, Jessica Arozqueta, Corbo, Marco, Limaye, Anay, Davis, Kara Lynn, Abu-Remaileh, Monther, Gomez-Ospina, Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543302/
https://www.ncbi.nlm.nih.gov/pubmed/37790525
http://dx.doi.org/10.21203/rs.3.rs-3263412/v1