Cargando…
A microglial activity state biomarker panel differentiates FTD-granulin and Alzheimer’s disease patients from controls
BACKGROUND: With the emergence of microglia-modulating therapies there is an urgent need for reliable biomarkers to evaluate microglial activation states. METHODS: Using mouse models and human induced pluripotent stem cell-derived microglia (hiMGL), genetically modified to yield the most opposite ho...
Autores principales: | Pesämaa, Ida, Müller, Stephan A., Robinson, Sophie, Darcher, Alana, Paquet, Dominik, Zetterberg, Henrik, Lichtenthaler, Stefan F., Haass, Christian |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543321/ https://www.ncbi.nlm.nih.gov/pubmed/37775827 http://dx.doi.org/10.1186/s13024-023-00657-w |
Ejemplares similares
-
Mechanisms of Granulin Deficiency: Lessons from Cellular and Animal Models
por: Kleinberger, Gernot, et al.
Publicado: (2012) -
Biomarkers for Microglial Activation in Alzheimer's Disease
por: Lautner, Ronald, et al.
Publicado: (2011) -
Granulin Knock Out Zebrafish Lack Frontotemporal Lobar Degeneration and Neuronal Ceroid Lipofuscinosis Pathology
por: Solchenberger, Barbara, et al.
Publicado: (2015) -
Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models
por: Sebastian Monasor, Laura, et al.
Publicado: (2020) -
Folding of Truncated Granulin Peptides
por: Takjoo, Rozita, et al.
Publicado: (2020)