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Anticodon sequence determines the impact of mistranslating tRNA(Ala) variants

Transfer RNAs (tRNAs) maintain translation fidelity through accurate charging by their cognate aminoacyl-tRNA synthetase and codon:anticodon base pairing with the mRNA at the ribosome. Mistranslation occurs when an amino acid not specified by the genetic message is incorporated into proteins and has...

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Detalles Bibliográficos
Autores principales: Cozma, Ecaterina, Rao, Megha, Dusick, Madison, Genereaux, Julie, Rodriguez-Mias, Ricard A., Villén, Judit, Brandl, Christopher J., Berg, Matthew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543346/
https://www.ncbi.nlm.nih.gov/pubmed/37776539
http://dx.doi.org/10.1080/15476286.2023.2257471