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Shared bias in H chain V-J pairing in naive and memory B cells

INTRODUCTION: H chain rearrangement in B cells is a two-step process where first D(H) binds J(H) , and only then V(H) is joined to the complex. As such, there is no direct rearrangement between V(H) and J(H) . RESULTS: Nevertheless, we here show that the V(H) JH combinations frequency in humans devi...

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Detalles Bibliográficos
Autores principales: Levi, Reut, Dvorkin, Shirit, Louzoun, Yoram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543446/
https://www.ncbi.nlm.nih.gov/pubmed/37790930
http://dx.doi.org/10.3389/fimmu.2023.1166116