Adaptive rewiring of purine metabolism promotes treatment resistance in H3K27M-mutant diffuse midline glioma

BACKGROUND: Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPGs), are a fatal form of brain cancer. These tumors often carry a driver mutation on histone H3 converting lysine 27 to methionine (H3K27M). DMG-H3K27M are characterized by altered metabolism and resistance to...

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Detalles Bibliográficos
Autores principales: Peterson, Erik R., Sajjakulnukit, Peter, Scott, Andrew J., Heaslip, Caleb, Andren, Anthony, Wilder-Romans, Kari, Zhou, Weihua, Palavalasa, Sravya, Korimerla, Navyateja, Lin, Angelica, Obrien, Alexandra, Kothari, Ayesha, Zhao, Zitong, Zhang, Li, Morgan, Meredith A., Venneti, Sriram, Koschmann, Carl, Jabado, Nada, Lyssiotis, Costas A., Castro, Maria G., Wahl, Daniel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543500/
https://www.ncbi.nlm.nih.gov/pubmed/37790517
http://dx.doi.org/10.21203/rs.3.rs-3317816/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543500/
https://www.ncbi.nlm.nih.gov/pubmed/37790517
http://dx.doi.org/10.21203/rs.3.rs-3317816/v1

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