Cargando…

Adaptive rewiring of purine metabolism promotes treatment resistance in H3K27M-mutant diffuse midline glioma

BACKGROUND: Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPGs), are a fatal form of brain cancer. These tumors often carry a driver mutation on histone H3 converting lysine 27 to methionine (H3K27M). DMG-H3K27M are characterized by altered metabolism and resistance to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Peterson, Erik R., Sajjakulnukit, Peter, Scott, Andrew J., Heaslip, Caleb, Andren, Anthony, Wilder-Romans, Kari, Zhou, Weihua, Palavalasa, Sravya, Korimerla, Navyateja, Lin, Angelica, Obrien, Alexandra, Kothari, Ayesha, Zhao, Zitong, Zhang, Li, Morgan, Meredith A., Venneti, Sriram, Koschmann, Carl, Jabado, Nada, Lyssiotis, Costas A., Castro, Maria G., Wahl, Daniel R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Journal Experts 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543500/ https://www.ncbi.nlm.nih.gov/pubmed/37790517 http://dx.doi.org/10.21203/rs.3.rs-3317816/v1

Ejemplares similares

DDRE-28. MECHANISTIC AND THERAPEUTIC LINKS BETWEEN PURINE BIOSYNTHESIS AND DNA DAMAGE IN GLIOBLASTOMA
por: Scott, Andrew, et al.
Publicado: (2021)

Interactions between Radiation and One-Carbon Metabolism
por: Korimerla, Navyateja, et al.
Publicado: (2022)

DDRE-24. TARGETING PURINE METABOLISM TO OVERCOME GLIOBLASTOMA THERAPY RESISTANCE
por: Zhou, Weihua, et al.
Publicado: (2021)

Purine metabolism regulates DNA repair and therapy resistance in glioblastoma
por: Zhou, Weihua, et al.
Publicado: (2020)

DDRE-30. THERAPEUTIC TARGETING OF DISRUPTED METABOLIC STATE IN DIFFUSE INTRINSIC PONTINE GLIOMA
por: Mbah, Nneka, et al.
Publicado: (2021)

Rewiring of purine metabolism in response to acidosis stress in glioma stem cells
por: Xu, Xiaoyu, et al.
Publicado: (2021)

De novo purine metabolism is a metabolic vulnerability of cancers with low p16 expression
por: Tangudu, Naveen Kumar, et al.
Publicado: (2023)

Histone H3 K27M-mediated regulation of cancer cell stemness and differentiation in diffuse midline glioma
por: Sharma, Monika, et al.
Publicado: (2023)

A large-scale analysis of targeted metabolomics data from heterogeneous biological samples provides insights into metabolite dynamics
por: Lee, Ho-Joon, et al.
Publicado: (2019)

DDRE-19. PHASE 0/I TRIAL OF MYCOPHENOLATE MOFETIL COMBINED WITH RADIATION TO OVERCOME GLIOBLASTOMA TREATMENT RESISTANCE BY TARGETING DE-NOVO PURINE METABOLISM
por: Umemura, Yoshie, et al.
Publicado: (2021)

H3K27M-mutant diffuse midline glioma with extensive intratumoral microthrombi in a young adult with COVID-19-associated coagulopathy
por: Pun, Matthew, et al.
Publicado: (2020)

BRAF activating mutations involving the β3-αC loop in V600E-negative anaplastic pleomorphic xanthoastrocytoma
por: Pratt, Drew, et al.
Publicado: (2018)

DIPG-09. Diffuse Midline Glioma-Adaptive Combinatory Trial (DMG-ACT): A biology-driven platform trial in pediatric and young adult patients with diffuse midline glioma
por: Franson, Andrea, et al.
Publicado: (2022)

Autopsy findings of previously described case of diffuse intrinsic pontine glioma-like tumor with EZHIP expression and molecular features of PFA ependymoma
por: Alturkustani, Murad, et al.
Publicado: (2021)

Therapeutic targeting of prenatal pontine ID1 signaling in diffuse midline glioma
por: Messinger, Dana, et al.
Publicado: (2022)

Asymptomatic Hypernatremia in an Infant with Midline Defects
por: Geminiganesan, Sangeetha, et al.
Publicado: (2021)

Multiomic characterization of pancreatic cancer-associated macrophage polarization reveals deregulated metabolic programs driven by the GM-CSF–PI3K pathway
por: Boyer, Seth, et al.
Publicado: (2022)

Auditory metabolomics, an approach to identify acute molecular effects of noise trauma
por: Ji, Lingchao, et al.
Publicado: (2019)

Purine metabolism promotes radioresistance and is a therapeutic target in glioblastoma
por: Zhou, Weihua, et al.
Publicado: (2020)

The Purins
por: Hopkins, Henry Reed
Publicado: (1910)

NKT cells adopt a glutamine-addicted phenotype to regulate their homeostasis and function
por: Kumar, Ajay, et al.
Publicado: (2022)

DIPG-06. Uncovering the FACTs in Diffuse Midline Glioma (DMG)
por: Holliday, Holly, et al.
Publicado: (2022)

Standardization of the liquid biopsy for pediatric diffuse midline glioma using ddPCR
por: Li, Daphne, et al.
Publicado: (2021)

Rewiring the cell
por: Wells, William A.
Publicado: (2004)

THE PURINES AND PURINE METABOLISM OF SOME TUMORS IN DOMESTIC ANIMALS
por: Long, Esmond R.
Publicado: (1913)

Glutamine Metabolism in Brain Tumors
por: Natarajan, Siva Kumar, et al.
Publicado: (2019)

Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways
por: Venneti, Sriram, et al.
Publicado: (2023)

Common biochemical properties of metabolic genes recurrently dysregulated in tumors
por: Oruganty, Krishnadev, et al.
Publicado: (2020)

DIPG-46. TARGETING THE METABOLIC ERK5-PFKFB3 AXIS IN PEDIATRIC DIFFUSE MIDLINE GLIOMA
por: Casillo, Stephanie, et al.
Publicado: (2023)

Rewiring makes the difference
por: Califano, Andrea
Publicado: (2011)

Metabolic rewiring in melanoma
por: Ratnikov, Boris I., et al.
Publicado: (2016)

Rewiring the Taste System
por: Lee, Hojoon, et al.
Publicado: (2017)

Small molecule activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, circumvents photoreceptor apoptosis
por: Wubben, Thomas J., et al.
Publicado: (2020)

The rewiring of America : the fiber optics revolution
por: Chaffee, C. David
Publicado: (1988)

FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle
por: Cader, M. Zaeem, et al.
Publicado: (2020)

FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle
por: Cader, M. Zaeem, et al.
Publicado: (2020)

Germinoma with Involvement of Midline and Off-Midline Intracranial Structures
por: Loto, Monica Graciela, et al.
Publicado: (2014)

CNSC-01. GABAERGIC NEURON-TO-GLIOMA SYNAPSES IN DIFFUSE MIDLINE GLIOMAS
por: Barron, Tara, et al.
Publicado: (2023)

Clinical, genomic, and epigenomic analyses of H3K27M-mutant diffuse midline glioma long-term survivors reveal a distinct group of tumors with MAPK pathway alterations
por: Roberts, Holly J., et al.
Publicado: (2023)

The Chemistry and Biology of Purines
por: Mautner, Henry G.
Publicado: (1957)

Cannot write session to /tmp/vufind_sessions/sess_26arv0qo45oudqplskk1s14cp1