Proteogenomic identification of an immunogenic antigen derived from human endogenous retrovirus in renal cell carcinoma

CD8(+) T cells can recognize tumor antigens displayed by HLA class I molecules and eliminate tumor cells. Despite their low tumor mutation burden, immune checkpoint blockade (ICB) is often beneficial in patients with renal cell carcinoma (RCC). Here, using a proteogenomic approach, we directly and c...

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Detalles Bibliográficos
Autores principales: Kobayashi, Shin, Tokita, Serina, Moniwa, Keigo, Kitahara, Katsuyuki, Iuchi, Hiromichi, Matsuo, Kazuhiko, Kakizaki, Hidehiro, Kanaseki, Takayuki, Torigoe, Toshihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543709/
https://www.ncbi.nlm.nih.gov/pubmed/37606040
http://dx.doi.org/10.1172/jci.insight.167712

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