B cell–intrinsic TLR7 expression drives severe lupus in TLR9-deficient mice

The endosomal Toll-like receptor 7 (TLR7) is a major driver of murine and human systemic lupus erythematosus (SLE). The role of TLR7 in lupus pathogenesis is enhanced when the regulatory role of TLR9 is absent. TLR7 signaling in plasmacytoid DCs (pDC) is generally thought to be a major driver of the...

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Detalles Bibliográficos
Autores principales: Cosgrove, Haylee A., Gingras, Sebastien, Kim, Minjung, Bastacky, Sheldon, Tilstra, Jeremy S., Shlomchik, Mark J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543715/
https://www.ncbi.nlm.nih.gov/pubmed/37606042
http://dx.doi.org/10.1172/jci.insight.172219

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543715/
https://www.ncbi.nlm.nih.gov/pubmed/37606042
http://dx.doi.org/10.1172/jci.insight.172219

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