Cargando…

B cell–intrinsic TLR7 expression drives severe lupus in TLR9-deficient mice

The endosomal Toll-like receptor 7 (TLR7) is a major driver of murine and human systemic lupus erythematosus (SLE). The role of TLR7 in lupus pathogenesis is enhanced when the regulatory role of TLR9 is absent. TLR7 signaling in plasmacytoid DCs (pDC) is generally thought to be a major driver of the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cosgrove, Haylee A., Gingras, Sebastien, Kim, Minjung, Bastacky, Sheldon, Tilstra, Jeremy S., Shlomchik, Mark J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543715/ https://www.ncbi.nlm.nih.gov/pubmed/37606042 http://dx.doi.org/10.1172/jci.insight.172219

Ejemplares similares

Murine lupus is neutrophil elastase-independent in the MRL.Fas(lpr) model
por: Gordon, Rachael A., et al.
Publicado: (2020)

Toll-like receptor 9 suppresses lupus disease in Fas-sufficient MRL Mice
por: Nickerson, Kevin M., et al.
Publicado: (2017)

Association of TLR7 and TLR9 genes polymorphisms in Egyptian patients with systemic lupus erythematosus
por: Azab, Marwa M., et al.
Publicado: (2022)

The Role of the Oxidative State and Innate Immunity Mediated by TLR7 and TLR9 in Lupus Nephritis
por: Echavarria, Raquel, et al.
Publicado: (2023)

TLR-9, but not TLR-2, TLR-3 and TLR-4, is upregulated on peripheral blood mononuclear cells of patients with active systemic lupus erythematosus
por: Papadimitraki, ED, et al.
Publicado: (2005)

Rubicon promotes rather than restricts murine lupus and is not required for LC3-associated phagocytosis
por: Gordon, Rachael A., et al.
Publicado: (2022)

Heterogeneity and clonality of kidney-infiltrating T cells in murine lupus nephritis
por: Smita, Shuchi, et al.
Publicado: (2022)

Roles of B Cell-Intrinsic TLR Signals in Systemic Lupus Erythematosus
por: Ma, Kongyang, et al.
Publicado: (2015)

Comparison of human B cell activation by TLR7 and TLR9 agonists
por: Hanten, John A, et al.
Publicado: (2008)

Aberrant Expression of TLR2, TLR7, TLR9, Splicing Variants of TLR4 and MYD88 in Chronic Lymphocytic Leukemia Patients
por: Skorka, Katarzyna, et al.
Publicado: (2021)

Expression of TLR2, TLR4, and TLR9 in dermatomyositis and polymyositis
por: Kim, Geun-Tae, et al.
Publicado: (2009)

The Role of TLR2, TLR4, and TLR9 in the Pathogenesis of Atherosclerosis
por: Roshan, Mohsin H. K., et al.
Publicado: (2016)

Effect of glucocorticoid on cytokines TLR9 and TLR7 in peripheral blood for patients with uveitis
por: Cui, Hong-Pei, et al.
Publicado: (2016)

TLR7 Signaling Drives the Development of Sjögren’s Syndrome
por: Wang, Yawen, et al.
Publicado: (2021)

DNA Nanoflowers’ Amelioration of Lupus Symptoms in Mice via Blockade of TLR7/9’s Signal
por: Wang, Jing, et al.
Publicado: (2022)

pDC Activation by TLR7/8 Ligand CL097 Compared to TLR7 Ligand IMQ or TLR9 Ligand CpG
por: Wu, Jing, et al.
Publicado: (2019)

Expression and activation of intracellular receptors TLR7, TLR8 and TLR9 in peripheral blood monocytes from HIV-infected patients
por: Valencia Pacheco, Guillermo J, et al.
Publicado: (2013)

TLR7/TLR8 activation and susceptibility genes synergize to breach gut barrier in a mouse model of lupus
por: Ma, Longhuan, et al.
Publicado: (2023)

Study of TLR3, TLR4 and TLR9 in breast carcinomas and their association with metastasis
por: González-Reyes, Salomé, et al.
Publicado: (2010)

TLR7 Deficiency Leads to TLR8 Compensative Regulation of Immune Response against JEV in Mice
por: Awais, Muhammad, et al.
Publicado: (2017)

TLR7 gain-of-function genetic variation causes human lupus
por: Brown, Grant J., et al.
Publicado: (2022)

CD180 Ligation Inhibits TLR7- and TLR9-Mediated Activation of Macrophages and Dendritic Cells Through the Lyn-SHP-1/2 Axis in Murine Lupus
por: Yang, Yonghong, et al.
Publicado: (2018)

Impaired Innate Immunity in Tlr4 (−/−) Mice but Preserved CD8(+) T Cell Responses against Trypanosoma cruzi in Tlr4-, Tlr2-, Tlr9- or Myd88-Deficient Mice
por: Oliveira, Ana-Carolina, et al.
Publicado: (2010)

TLR4 and TLR9 Expression in Different Phenotypes of Rhinitis
por: Lauriello, Maria, et al.
Publicado: (2012)

Below the surface: The inner lives of TLR4 and TLR9
por: Marongiu, Laura, et al.
Publicado: (2019)

Combined TLR7/8 and TLR9 Ligands Potentiate the Activity of a Schistosoma japonicum DNA Vaccine
por: Wang, Xuefeng, et al.
Publicado: (2013)

TLR7/TLR9- and B Cell Receptor-Signaling Crosstalk: Promotion of Potentially Dangerous B Cells
por: Suthers, Amy N., et al.
Publicado: (2017)

Phenotypic consequences of TLR7-driven interferon and proinflammatory cytokine production in lupus
por: Reeves, Westley H, et al.
Publicado: (2014)

From monogenic lupus to TLR7/MyD88-targeted therapy
por: Wang, Min, et al.
Publicado: (2022)

TLR7 Activation Accelerates Cardiovascular Pathology in a Mouse Model of Lupus
por: Elshikha, Ahmed S., et al.
Publicado: (2022)

The role of TLR7 agonists in modulating COVID-19 severity in subjects with loss-of-function TLR7 variants
por: Naushad, Shaik Mohammad, et al.
Publicado: (2023)

The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling
por: Brinkmann, Melanie M., et al.
Publicado: (2007)

Unc93 homolog B1 restricts systemic lethal inflammation by orchestrating TLR7 and TLR9 response
por: Fukui, Ryutaro, et al.
Publicado: (2012)

Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9
por: Guiducci, Cristiana, et al.
Publicado: (2010)

Differential Adjuvant Activities of TLR7 and TLR9 Agonists Inversely Correlate with Nitric Oxide and PGE(2) Production
por: Lee, Jinhee, et al.
Publicado: (2015)

A Combined TLR7/TLR9/GATA3 Score Can Predict Prognosis in Biliary Tract Cancer
por: Branchi, Vittorio, et al.
Publicado: (2021)

Association of Genetic Polymorphisms in TLR3, TLR4, TLR7, and TLR8 with the Clinical Forms of Dengue in Patients from Veracruz, Mexico
por: Posadas-Mondragón, Araceli, et al.
Publicado: (2020)

Disease in the Pld4(thss/thss) Model of Murine Lupus Requires TLR9
por: Gavin, Amanda L., et al.
Publicado: (2023)

Endosomal TLR3, TLR7, and TLR8 control neuronal morphology through different transcriptional programs
por: Hung, Yun-Fen, et al.
Publicado: (2018)

Association of TLR4 and TLR9 polymorphisms and haplotypes with cervical cancer susceptibility
por: Pandey, Nilesh O., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_2k26prar2t0al6s1cs2bbboej3