Responders to low-dose ATG induce CD4(+) T cell exhaustion in type 1 diabetes

BACKGROUND: Low-dose anti–thymocyte globulin (ATG) transiently preserves C-peptide and lowers HbA1c in individuals with recent-onset type 1 diabetes (T1D); however, the mechanisms of action and features of the response remain unclear. Here, we characterized the post hoc immunological outcomes of ATG...

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Detalles Bibliográficos
Autores principales: Jacobsen, Laura M., Diggins, Kirsten, Blanchfield, Lori, McNichols, James, Perry, Daniel J., Brant, Jason, Dong, Xiaoru, Bacher, Rhonda, Gersuk, Vivian H., Schatz, Desmond A., Atkinson, Mark A., Mathews, Clayton E., Haller, Michael J., Long, S. Alice, Linsley, Peter S., Brusko, Todd M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Clinical Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543726/
https://www.ncbi.nlm.nih.gov/pubmed/37432736
http://dx.doi.org/10.1172/jci.insight.161812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543726/
https://www.ncbi.nlm.nih.gov/pubmed/37432736
http://dx.doi.org/10.1172/jci.insight.161812

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