A Carbonic Anhydrase IX/SLC1A5 Axis Regulates Glutamine Metabolism Dependent Ferroptosis in Hypoxic Tumor Cells

The ability of tumor cells to alter their metabolism to support survival and growth presents a challenge to effectively treat cancers. Carbonic anhydrase IX (CAIX) is a hypoxia-induced, metabolic enzyme that plays a crucial role in pH regulation in tumor cells. Recently, through a synthetic lethal s...

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Detalles Bibliográficos
Autores principales: Venkateswaran, Geetha, McDonald, Paul C., Chafe, Shawn C., Brown, Wells S., Gerbec, Zachary J., Awrey, Shannon J., Parker, Seth J., Dedhar, Shoukat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Targeting Drug Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543979/
https://www.ncbi.nlm.nih.gov/pubmed/37348875
http://dx.doi.org/10.1158/1535-7163.MCT-23-0041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543979/
https://www.ncbi.nlm.nih.gov/pubmed/37348875
http://dx.doi.org/10.1158/1535-7163.MCT-23-0041

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