MTX-13, a Novel PTK7-Directed Antibody–Drug Conjugate with Widened Therapeutic Index Shows Sustained Tumor Regressions for a Broader Spectrum of PTK7-Positive Tumors

Protein tyrosine kinase 7 (PTK7) is a Wnt signaling pathway protein implicated in cancer development and metastasis. When using a potent microtubule inhibitor (Aur0101), PTK7-targeting antibody–drug conjugate (ADC), h6M24-vc0101 (PF-06647020/cofetuzumab pelidotin) is efficacious only in limited tumo...

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Detalles Bibliográficos
Autores principales: Kong, Chao, Pu, Junyi, Zhao, Qianqian, Weng, Weining, Ma, Linjie, Qian, Yu, Hu, Wenhao, Meng, Xun, Meng, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
First Disclosures
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544008/
https://www.ncbi.nlm.nih.gov/pubmed/37352387
http://dx.doi.org/10.1158/1535-7163.MCT-23-0164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544008/
https://www.ncbi.nlm.nih.gov/pubmed/37352387
http://dx.doi.org/10.1158/1535-7163.MCT-23-0164

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