ΔNp63 silencing, DNA methylation shifts, and epithelial-mesenchymal transition resulted from TAp63 genome editing in squamous cell carcinoma

TP63 (p63) is strongly expressed in lower-grade carcinomas of the head and neck, skin, breast, and urothelium to maintain a well-differentiated phenotype. TP63 has two transcription start sites at exons 1 and 3′ that produce TAp63 and ΔNp63 isoforms, respectively. The major protein, ΔNp63α, epigenet...

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Detalles Bibliográficos
Autores principales: Katoh, Iyoko, Tsukinoki, Keiichi, Hata, Ryu-Ichiro, Kurata, Shun-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544079/
https://www.ncbi.nlm.nih.gov/pubmed/37778252
http://dx.doi.org/10.1016/j.neo.2023.100938

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544079/
https://www.ncbi.nlm.nih.gov/pubmed/37778252
http://dx.doi.org/10.1016/j.neo.2023.100938

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