Mocetinostat activates Krüppel-like factor 4 and protects against tissue destruction and inflammation in osteoarthritis

Osteoarthritis (OA) is the most common joint disorder, and disease-modifying OA drugs (DMOADs) represent a major need in OA management. Krüppel-like factor 4 (KLF4) is a central transcription factor upregulating regenerative and protective functions in joint tissues. This study was aimed to identify...

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Detalles Bibliográficos
Autores principales: Kawata, Manabu, McClatchy, Daniel B., Diedrich, Jolene K., Olmer, Merissa, Johnson, Kristen A., Yates, John R., Lotz, Martin K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544226/
https://www.ncbi.nlm.nih.gov/pubmed/37681413
http://dx.doi.org/10.1172/jci.insight.170513

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544226/
https://www.ncbi.nlm.nih.gov/pubmed/37681413
http://dx.doi.org/10.1172/jci.insight.170513

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