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Mocetinostat activates Krüppel-like factor 4 and protects against tissue destruction and inflammation in osteoarthritis

Osteoarthritis (OA) is the most common joint disorder, and disease-modifying OA drugs (DMOADs) represent a major need in OA management. Krüppel-like factor 4 (KLF4) is a central transcription factor upregulating regenerative and protective functions in joint tissues. This study was aimed to identify...

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Detalles Bibliográficos
Autores principales:	Kawata, Manabu, McClatchy, Daniel B., Diedrich, Jolene K., Olmer, Merissa, Johnson, Kristen A., Yates, John R., Lotz, Martin K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544226/ https://www.ncbi.nlm.nih.gov/pubmed/37681413 http://dx.doi.org/10.1172/jci.insight.170513

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