Hepatic FASN deficiency differentially affects nonalcoholic fatty liver disease and diabetes in mouse obesity models

Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes are interacting comorbidities of obesity, and increased hepatic de novo lipogenesis (DNL), driven by hyperinsulinemia and carbohydrate overload, contributes to their pathogenesis. Fatty acid synthase (FASN), a key enzyme of hepatic DNL, is...

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Detalles Bibliográficos
Autores principales: Matsukawa, Toshiya, Yagi, Takashi, Uchida, Tohru, Sakai, Mashito, Mitsushima, Masaru, Naganuma, Takao, Yano, Hiroyuki, Inaba, Yuka, Inoue, Hiroshi, Yanagida, Keisuke, Uematsu, Masaaki, Nakao, Kazuki, Nakao, Harumi, Aiba, Atsu, Nagashima, Yoji, Kubota, Tetsuya, Kubota, Naoto, Izumida, Yoshihiko, Yahagi, Naoya, Unoki-Kubota, Hiroyuki, Kaburagi, Yasushi, Asahara, Shun-ichiro, Kido, Yoshiaki, Shindou, Hideo, Itoh, Michiko, Ogawa, Yoshihiro, Minami, Shiro, Terauchi, Yasuo, Tobe, Kazuyuki, Ueki, Kohjiro, Kasuga, Masato, Matsumoto, Michihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544238/
https://www.ncbi.nlm.nih.gov/pubmed/37681411
http://dx.doi.org/10.1172/jci.insight.161282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544238/
https://www.ncbi.nlm.nih.gov/pubmed/37681411
http://dx.doi.org/10.1172/jci.insight.161282

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