Improved computational epitope profiling using structural models identifies a broader diversity of antibodies that bind to the same epitope

The function of an antibody is intrinsically linked to the epitope it engages. Clonal clustering methods, based on sequence identity, are commonly used to group antibodies that will bind to the same epitope. However, such methods neglect the fact that antibodies with highly diverse sequences can exh...

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Detalles Bibliográficos
Autores principales: Spoendlin, Fabian C., Abanades, Brennan, Raybould, Matthew I. J., Wong, Wing Ki, Georges, Guy, Deane, Charlotte M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544996/
https://www.ncbi.nlm.nih.gov/pubmed/37790877
http://dx.doi.org/10.3389/fmolb.2023.1237621

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544996/
https://www.ncbi.nlm.nih.gov/pubmed/37790877
http://dx.doi.org/10.3389/fmolb.2023.1237621

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