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Mechanistic multiscale modelling of energy metabolism in human astrocytes reveals the impact of morphology changes in Alzheimer’s Disease
Astrocytes with their specialised morphology are essential for brain homeostasis as metabolic mediators between blood vessels and neurons. In neurodegenerative diseases such as Alzheimer’s disease (AD), astrocytes adopt reactive profiles with molecular and morphological changes that could lead to th...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545114/ https://www.ncbi.nlm.nih.gov/pubmed/37729344 http://dx.doi.org/10.1371/journal.pcbi.1011464 |