Regulation of defective mitochondrial DNA accumulation and transmission in C. elegans by the programmed cell death and aging pathways

The heteroplasmic state of eukaryotic cells allows for cryptic accumulation of defective mitochondrial genomes (mtDNA). ‘Purifying selection’ mechanisms operate to remove such dysfunctional mtDNAs. We found that activators of programmed cell death (PCD), including the CED-3 and CSP-1 caspases, the B...

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Detalles Bibliográficos
Autores principales: Flowers, Sagen, Kothari, Rushali, Torres Cleuren, Yamila N, Alcorn, Melissa R, Ewe, Chee Kiang, Alok, Geneva, Fiallo, Samantha L, Joshi, Pradeep M, Rothman, Joel H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545429/
https://www.ncbi.nlm.nih.gov/pubmed/37782016
http://dx.doi.org/10.7554/eLife.79725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545429/
https://www.ncbi.nlm.nih.gov/pubmed/37782016
http://dx.doi.org/10.7554/eLife.79725

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