Cargando…

Lysosomal polygenic risk is associated with the severity of neuropathology in Lewy body disease

Intraneuronal accumulation of misfolded α-synuclein is the pathological hallmark of Parkinson’s disease and dementia with Lewy bodies, often co-occurring with variable degrees of Alzheimer’s disease related neuropathology. Genetic association studies have successfully identified common variants asso...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tunold, Jon-Anders, Tan, Manuela M X, Koga, Shunsuke, Geut, Hanneke, Rozemuller, Annemieke J M, Valentino, Rebecca, Sekiya, Hiroaki, Martin, Nicholas B, Heckman, Michael G, Bras, Jose, Guerreiro, Rita, Dickson, Dennis W, Toft, Mathias, van de Berg, Wilma D J, Ross, Owen A, Pihlstrøm, Lasse
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545498/ https://www.ncbi.nlm.nih.gov/pubmed/37247383 http://dx.doi.org/10.1093/brain/awad183

Ejemplares similares

APOE and MAPT Are Associated With Dementia in Neuropathologically Confirmed Parkinson's Disease
por: Tunold, Jon-Anders, et al.
Publicado: (2021)

Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathology
por: Pihlstrøm, Lasse, et al.
Publicado: (2022)

Transcriptomic profiling of Parkinson's disease brains reveals disease stage specific gene expression changes
por: Cappelletti, Chiara, et al.
Publicado: (2023)

Neuropathology and molecular diagnosis of Synucleinopathies
por: Koga, Shunsuke, et al.
Publicado: (2021)

Mitochondrial genomic variation in dementia with Lewy bodies: association with disease risk and neuropathological measures
por: Valentino, Rebecca R., et al.
Publicado: (2022)

Neuropathological correlates of parkinsonian disorders in a large Dutch autopsy series
por: Geut, H., et al.
Publicado: (2020)

Neuropathology and emerging biomarkers in corticobasal syndrome
por: Koga, Shunsuke, et al.
Publicado: (2022)

Gene-Wise Association of Variants in Four Lysosomal Storage Disorder Genes in Neuropathologically Confirmed Lewy Body Disease
por: Clark, Lorraine N., et al.
Publicado: (2015)

β-Amyloid PET and neuropathology in dementia with Lewy bodies
por: Kantarci, Kejal, et al.
Publicado: (2020)

Associations of mitochondrial genomic variation with corticobasal degeneration, progressive supranuclear palsy, and neuropathological tau measures
por: Valentino, Rebecca R., et al.
Publicado: (2020)

Neuropathology of Parkinson’s disease after focused ultrasound thalamotomy
por: Koga, Shunsuke, et al.
Publicado: (2022)

The Genetics of Dementia with Lewy Bodies: Current Understanding and Future Directions
por: Orme, Tatiana, et al.
Publicado: (2018)

The Neuropathology of Gluten-Related Neurological Disorders: A Systematic Review
por: Rouvroye, Maxine D, et al.
Publicado: (2020)

Neuropathology of incidental Lewy body & prodromal Parkinson’s disease
por: Koeglsperger, Thomas, et al.
Publicado: (2023)

Discrepancy between distribution of alpha-synuclein oligomers and Lewy-related pathology in Parkinson’s disease
por: Sekiya, Hiroaki, et al.
Publicado: (2022)

Reply to: Genome-wide association studies of polygenic risk score-derived phenotypes may lead to inflated false positive rates
por: Guerreiro, Rita, et al.
Publicado: (2023)

Neuropathological Changes in Dementia With Lewy Bodies and the Cingulate Island Sign
por: Patterson, Lina, et al.
Publicado: (2019)

Integrative analysis identifies bHLH transcription factors as contributors to Parkinson’s disease risk mechanisms
por: Berge-Seidl, Victoria, et al.
Publicado: (2021)

Axonal degeneration in the anterior insular cortex is associated with Alzheimer’s co-pathology in Parkinson’s disease and dementia with Lewy bodies
por: Fathy, Yasmine Y., et al.
Publicado: (2022)

Clinical and Pathological Phenotypes of LRP10 Variant Carriers with Dementia
por: Vergouw, Leonie J. M., et al.
Publicado: (2020)

Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies
por: Bras, Jose, et al.
Publicado: (2014)

Genome-wide association of polygenic risk extremes for Alzheimer's disease in the UK Biobank
por: Gouveia, Catarina, et al.
Publicado: (2022)

Allele-specific expression of Parkinson’s disease susceptibility genes in human brain
por: Langmyhr, Margrete, et al.
Publicado: (2021)

Neuropathology and cognitive performance in self-reported cognitively healthy centenarians
por: Ganz, Andrea B., et al.
Publicado: (2018)

LRP10 interacts with SORL1 in the intracellular vesicle trafficking pathway in non-neuronal brain cells and localises to Lewy bodies in Parkinson’s disease and dementia with Lewy bodies
por: Grochowska, Martyna M., et al.
Publicado: (2021)

Mixed Alzheimer's and Lewy-related Pathology Can Cause Corticobasal Syndrome with Visual Hallucinations
por: Kasanuki, Koji, et al.
Publicado: (2019)

Risk variants of the α-synuclein locus and REM sleep behavior disorder in Parkinson’s disease: a genetic association study
por: Bjørnarå, Kari Anne, et al.
Publicado: (2018)

Association between clinical symptoms and post‐mortem neuropathology in dementia with Lewy bodies
por: Kaneko, Yoshitsugu, et al.
Publicado: (2020)

Characterization of Brain Lysosomal Activities in GBA-Related and Sporadic Parkinson’s Disease and Dementia with Lewy Bodies
por: Moors, Tim E., et al.
Publicado: (2018)

Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update
por: Mackenzie, Ian R. A., et al.
Publicado: (2009)

Neuropathological studies of serotonergic and noradrenergic systems in Lewy body disease patients with delusion or depression
por: Mizutani, Masashi, et al.
Publicado: (2022)

In situ proximity labeling identifies Lewy pathology molecular interactions in the human brain
por: Killinger, Bryan A., et al.
Publicado: (2022)

Normal Aging Brain Collection Amsterdam (NABCA): A comprehensive collection of postmortem high-field imaging, neuropathological and morphometric datasets of non-neurological controls
por: Jonkman, Laura E., et al.
Publicado: (2019)

The neuropathological diagnosis of Alzheimer’s disease
por: DeTure, Michael A., et al.
Publicado: (2019)

Severe hyposmia distinguishes neuropathologically confirmed dementia with Lewy bodies from Alzheimer’s disease dementia
por: Beach, Thomas G., et al.
Publicado: (2020)

Performance of αSynuclein RT-QuIC in relation to neuropathological staging of Lewy body disease
por: Hall, Sara, et al.
Publicado: (2022)

Differential Neuropathology, Genetics, and Transcriptomics in Two Kindred Cases with Alzheimer’s Disease and Lewy Body Dementia
por: Palmieri, Ilaria, et al.
Publicado: (2022)

Glucocerebrosidase Mutations alter the endoplasmic reticulum and lysosomes in Lewy body disease
por: Kurzawa-Akanbi, Marzena, et al.
Publicado: (2012)

Granulins rescue inflammation, lysosome dysfunction, and neuropathology in a mouse model of progranulin deficiency
por: Root, Jessica, et al.
Publicado: (2023)

Neuropathology of FMR1-premutation carriers presenting with dementia and neuropsychiatric symptoms
por: Dijkstra, Anke A, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_o4hiq3lvrptjsdldvmbaaih7hr