IL-12 sensing in neurons induces neuroprotective CNS tissue adaptation and attenuates neuroinflammation in mice

Interleukin-12 (IL-12) is a potent driver of type 1 immunity. Paradoxically, in autoimmune conditions, including of the CNS, IL-12 reduces inflammation. The underlying mechanism behind these opposing properties and the involved cellular players remain elusive. Here we map IL-12 receptor (IL-12R) exp...

Descripción completa

Detalles Bibliográficos
Autores principales: Andreadou, Myrto, Ingelfinger, Florian, De Feo, Donatella, Cramer, Teresa L. M., Tuzlak, Selma, Friebel, Ekaterina, Schreiner, Bettina, Eede, Pascale, Schneeberger, Shirin, Geesdorf, Maria, Ridder, Frederike, Welsh, Christina A., Power, Laura, Kirschenbaum, Daniel, Tyagarajan, Shiva K., Greter, Melanie, Heppner, Frank L., Mundt, Sarah, Becher, Burkhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545539/
https://www.ncbi.nlm.nih.gov/pubmed/37749256
http://dx.doi.org/10.1038/s41593-023-01435-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545539/
https://www.ncbi.nlm.nih.gov/pubmed/37749256
http://dx.doi.org/10.1038/s41593-023-01435-z

Ejemplares similares