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WDR4 promotes the progression and lymphatic metastasis of bladder cancer via transcriptional down-regulation of ARRB2

Lymph node (LN) metastasis is one of the key prognostic factors in bladder cancer, but its underlying mechanisms remain unclear. Here, we found that elevated expression of WD repeat domain 4 (WDR4) in bladder cancer correlated with worse prognosis. WDR4 can promote the LN metastasis and proliferatio...

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Detalles Bibliográficos
Autores principales: Wang, Guoli, He, Xin, Dai, Huiqi, Lin, Lingyi, Cao, Wenmin, Fu, Yao, Diao, Wenli, Ding, Meng, Zhang, Qing, Chen, Wei, Guo, Hongqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545698/
https://www.ncbi.nlm.nih.gov/pubmed/37783676
http://dx.doi.org/10.1038/s41389-023-00493-z