Structure-based drug discovery of a corticotropin-releasing hormone receptor 1 antagonist using an X-ray free-electron laser

Thus far, attempts to develop drugs that target corticotropin-releasing hormone receptor 1 (CRF(1)R), a drug target in stress-related therapy, have been unsuccessful. Studies have focused on using high-resolution G protein-coupled receptor (GPCR) structures to develop drugs. X-ray free-electron lase...

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Detalles Bibliográficos
Autores principales: Kim, Hoyoung, Lim, Taehyun, Ha, Go Eun, Lee, Jee-Young, Kim, Jun-Woo, Chang, Nienping, Kim, Si Hyun, Kim, Ki Hun, Lee, Jaeick, Cho, Yongju, Kim, Byeong Wook, Abrahamsson, Alva, Kim, Sung Hwan, Kim, Hyo-Ji, Park, Sehan, Lee, Sang Jae, Park, Jaehyun, Cheong, Eunji, Kim, B. Moon, Cho, Hyun-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545732/
https://www.ncbi.nlm.nih.gov/pubmed/37653040
http://dx.doi.org/10.1038/s12276-023-01082-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545732/
https://www.ncbi.nlm.nih.gov/pubmed/37653040
http://dx.doi.org/10.1038/s12276-023-01082-1

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