Development of cyclopeptide inhibitors of cGAS targeting protein-DNA interaction and phase separation

Cyclic GMP-AMP synthase (cGAS) is an essential sensor of aberrant cytosolic DNA for initiating innate immunity upon invading pathogens and cellular stress, which is considered as a potential drug target for autoimmune and autoinflammatory diseases. Here, we report the discovery of a class of cyclope...

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Detalles Bibliográficos
Autores principales: Wang, Xiaoquan, Wang, Youqiao, Cao, Anqi, Luo, Qinhong, Chen, Daoyuan, Zhao, Weiqi, Xu, Jun, Li, Qinkai, Bu, Xianzhang, Quan, Junmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545747/
https://www.ncbi.nlm.nih.gov/pubmed/37783727
http://dx.doi.org/10.1038/s41467-023-41892-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545747/
https://www.ncbi.nlm.nih.gov/pubmed/37783727
http://dx.doi.org/10.1038/s41467-023-41892-5

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