2-Oxabicyclo[2.2.2]octane as a new bioisostere of the phenyl ring

The phenyl ring is a basic structural element in chemistry. Here, we show the design, synthesis, and validation of its new saturated bioisostere with improved physicochemical properties − 2-oxabicyclo[2.2.2]octane. The design of the structure is based on the analysis of the advantages and disadvanta...

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Detalles Bibliográficos
Autores principales: Levterov, Vadym V., Panasiuk, Yaroslav, Sahun, Kateryna, Stashkevych, Oleksandr, Badlo, Valentyn, Shablykin, Oleh, Sadkova, Iryna, Bortnichuk, Lina, Klymenko-Ulianov, Oleksii, Holota, Yuliia, Lachmann, Leonid, Borysko, Petro, Horbatok, Kateryna, Bodenchuk, Iryna, Bas, Yuliia, Dudenko, Dmytro, Mykhailiuk, Pavel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545790/
https://www.ncbi.nlm.nih.gov/pubmed/37783681
http://dx.doi.org/10.1038/s41467-023-41298-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545790/
https://www.ncbi.nlm.nih.gov/pubmed/37783681
http://dx.doi.org/10.1038/s41467-023-41298-3

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