Specific peptide conjugation to a therapeutic antibody leads to enhanced therapeutic potency and thermal stability by reduced Fc dynamics

Antibody–drug conjugates are powerful tools for combatting a wide array of cancers. Drug conjugation to a therapeutic antibody often alters molecular characteristics, such as hydrophobicity and effector function, resulting in quality deterioration. To develop a drug conjugation methodology that main...

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Detalles Bibliográficos
Autores principales: Kiyoshi, Masato, Nakakido, Makoto, Rafique, Abdur, Tada, Minoru, Aoyama, Michihiko, Terao, Yosuke, Nagatoishi, Satoru, Shibata, Hiroko, Ide, Teruhiko, Tsumoto, Kouhei, Ito, Yuji, Ishii-Watabe, Akiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545826/
https://www.ncbi.nlm.nih.gov/pubmed/37783706
http://dx.doi.org/10.1038/s41598-023-43431-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545826/
https://www.ncbi.nlm.nih.gov/pubmed/37783706
http://dx.doi.org/10.1038/s41598-023-43431-0

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