The potential and challenges of targeting MTAP-negative cancers beyond synthetic lethality

Approximately 15% of cancers exhibit loss of the chromosomal locus 9p21.3 – the genomic location of the tumour suppressor gene CDKN2A and the methionine salvage gene methylthioadenosine phosphorylase (MTAP). A loss of MTAP increases the pool of its substrate methylthioadenosine (MTA), which binds to...

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Detalles Bibliográficos
Autores principales: Bray, Chandler, Balcells, Cristina, McNeish, Iain A., Keun, Hector C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10546069/
https://www.ncbi.nlm.nih.gov/pubmed/37795443
http://dx.doi.org/10.3389/fonc.2023.1264785

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10546069/
https://www.ncbi.nlm.nih.gov/pubmed/37795443
http://dx.doi.org/10.3389/fonc.2023.1264785

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