Azetidine synthesis by La(OTf)(3)-catalyzed intramolecular regioselective aminolysis of cis-3,4-epoxy amines

Azetidine is a prevalent structural motif found in various biologically active compounds. In this research paper, we report La(OTf)(3)-catalyzed intramolecular regioselective aminolysis of cis-3,4-epoxy amines to afford azetidines. This reaction proceeded in high yields even in the presence of acid-...

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Autores principales: Kuriyama, Yuse, Sasano, Yusuke, Iwabuchi, Yoshiharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10546187/
https://www.ncbi.nlm.nih.gov/pubmed/37795386
http://dx.doi.org/10.3389/fchem.2023.1251299
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author Kuriyama, Yuse
Sasano, Yusuke
Iwabuchi, Yoshiharu
author_facet Kuriyama, Yuse
Sasano, Yusuke
Iwabuchi, Yoshiharu
author_sort Kuriyama, Yuse
collection PubMed
description Azetidine is a prevalent structural motif found in various biologically active compounds. In this research paper, we report La(OTf)(3)-catalyzed intramolecular regioselective aminolysis of cis-3,4-epoxy amines to afford azetidines. This reaction proceeded in high yields even in the presence of acid-sensitive and Lewis basic functional groups.
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spelling pubmed-105461872023-10-04 Azetidine synthesis by La(OTf)(3)-catalyzed intramolecular regioselective aminolysis of cis-3,4-epoxy amines Kuriyama, Yuse Sasano, Yusuke Iwabuchi, Yoshiharu Front Chem Chemistry Azetidine is a prevalent structural motif found in various biologically active compounds. In this research paper, we report La(OTf)(3)-catalyzed intramolecular regioselective aminolysis of cis-3,4-epoxy amines to afford azetidines. This reaction proceeded in high yields even in the presence of acid-sensitive and Lewis basic functional groups. Frontiers Media S.A. 2023-09-19 /pmc/articles/PMC10546187/ /pubmed/37795386 http://dx.doi.org/10.3389/fchem.2023.1251299 Text en Copyright © 2023 Kuriyama, Sasano and Iwabuchi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Kuriyama, Yuse
Sasano, Yusuke
Iwabuchi, Yoshiharu
Azetidine synthesis by La(OTf)(3)-catalyzed intramolecular regioselective aminolysis of cis-3,4-epoxy amines
title Azetidine synthesis by La(OTf)(3)-catalyzed intramolecular regioselective aminolysis of cis-3,4-epoxy amines
title_full Azetidine synthesis by La(OTf)(3)-catalyzed intramolecular regioselective aminolysis of cis-3,4-epoxy amines
title_fullStr Azetidine synthesis by La(OTf)(3)-catalyzed intramolecular regioselective aminolysis of cis-3,4-epoxy amines
title_full_unstemmed Azetidine synthesis by La(OTf)(3)-catalyzed intramolecular regioselective aminolysis of cis-3,4-epoxy amines
title_short Azetidine synthesis by La(OTf)(3)-catalyzed intramolecular regioselective aminolysis of cis-3,4-epoxy amines
title_sort azetidine synthesis by la(otf)(3)-catalyzed intramolecular regioselective aminolysis of cis-3,4-epoxy amines
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10546187/
https://www.ncbi.nlm.nih.gov/pubmed/37795386
http://dx.doi.org/10.3389/fchem.2023.1251299
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AT iwabuchiyoshiharu azetidinesynthesisbylaotf3catalyzedintramolecularregioselectiveaminolysisofcis34epoxyamines

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