Reconciling intrinsic properties of activating TNF receptors by native ligands versus synthetic agonists

The extracellular domain of tumor necrosis factor receptors (TNFR) generally require assembly into a homotrimeric quaternary structure as a prerequisite for initiation of signaling via the cytoplasmic domains. TNF receptor homotrimers are natively activated by similarly homo-trimerized TNF ligands,...

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Detalles Bibliográficos
Autores principales: Fromm, George, de Silva, Suresh, Schreiber, Taylor H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10546206/
https://www.ncbi.nlm.nih.gov/pubmed/37795079
http://dx.doi.org/10.3389/fimmu.2023.1236332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10546206/
https://www.ncbi.nlm.nih.gov/pubmed/37795079
http://dx.doi.org/10.3389/fimmu.2023.1236332

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