Genome-wide association studies of human and rat BMI converge on synapse, epigenome, and hormone signaling networks

A vexing observation in genome-wide association studies (GWASs) is that parallel analyses in different species may not identify orthologous genes. Here, we demonstrate that cross-species translation of GWASs can be greatly improved by an analysis of co-localization within molecular networks. Using b...

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Detalles Bibliográficos
Autores principales: Wright, Sarah N., Leger, Brittany S., Rosenthal, Sara Brin, Liu, Sophie N., Jia, Tongqiu, Chitre, Apurva S., Polesskaya, Oksana, Holl, Katie, Gao, Jianjun, Cheng, Riyan, Martinez, Angel Garcia, George, Anthony, Gileta, Alexander F., Han, Wenyan, Netzley, Alesa H., King, Christopher P., Lamparelli, Alexander, Martin, Connor, St. Pierre, Celine L., Wang, Tengfei, Bimschleger, Hannah, Richards, Jerry, Ishiwari, Keita, Chen, Hao, Flagel, Shelly B., Meyer, Paul, Robinson, Terry E., Woods, Leah C. Solberg, Kreisberg, Jason F., Ideker, Trey, Palmer, Abraham A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10546330/
https://www.ncbi.nlm.nih.gov/pubmed/37527041
http://dx.doi.org/10.1016/j.celrep.2023.112873

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10546330/
https://www.ncbi.nlm.nih.gov/pubmed/37527041
http://dx.doi.org/10.1016/j.celrep.2023.112873

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