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CHCHD2 mediates glioblastoma cell proliferation, mitochondrial metabolism, hypoxia-induced invasion and therapeutic resistance

Glioblastoma (GBM) is the most common and malignant primary brain tumor affecting adults and remains incurable. The mitochondrial coiled-coil-helix-coiled-coi l-helix domain-containing protein 2 (CHCHD2) has been demonstrated to mediate mitochondrial respiration, nuclear gene expression and cell mig...

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Detalles Bibliográficos
Autores principales: Lumibao, Jan C., Haak, Payton L., Kolossov, Vladimir L., Chen, Jee-Wei Emily, Stutchman, Jeremy, Ruiz, Alejandra, Sivaguru, Mayandi, Sarkaria, Jann N., Harley, Brendan A.C., Steelman, Andrew J., Gaskins, H. Rex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10546377/
https://www.ncbi.nlm.nih.gov/pubmed/37654190
http://dx.doi.org/10.3892/ijo.2023.5565